The comparative immunology of wild and laboratory mice, Mus musculus domesticus
Identifieur interne : 000E51 ( Main/Exploration ); précédent : 000E50; suivant : 000E52The comparative immunology of wild and laboratory mice, Mus musculus domesticus
Auteurs : Stephen Abolins ; Elizabeth C. King ; Luke Lazarou ; Laura Weldon ; Louise Hughes ; Paul Drescher ; John G. Raynes ; Julius C. R. Hafalla ; Mark E. Viney ; Eleanor M. RileySource :
- Nature Communications [ 2041-1723 ] ; 2017.
Abstract
The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast,
The online version of this article (doi:10.1038/ncomms14811) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/ncomms14811
PubMed: 28466840
PubMed Central: 5418598
Affiliations:
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Riley</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.8991.9</institution-id><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution>Department of Immunology and Infection,</institution><institution>London School of Hygiene and Tropical Medicine,</institution></institution-wrap>Keppel Street, London, WC1E 7HT UK</nlm:aff><wicri:noCountry code="subfield">WC1E 7HT UK</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, <italic>in vitro</italic> cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/ncomms14811) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Pardo Manuel De Villena, F" uniqKey="Pardo Manuel De Villena F">F Pardo-Manuel de Villena</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Mcmillan, L" uniqKey="Mcmillan L">L McMillan</name></author><author><name sortKey="Threadgill, Dw" uniqKey="Threadgill D">DW Threadgill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name 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uniqKey="Peterson D">D Peterson</name></author><author><name sortKey="Filipski, A" uniqKey="Filipski A">A Filipski</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loveless, Rw" uniqKey="Loveless R">RW Loveless</name></author><author><name sortKey="Floyd O Sullivan, G" uniqKey="Floyd O Sullivan G">G Floyd-O'Sullivan</name></author><author><name sortKey="Raynesm, Jg" uniqKey="Raynesm J">JG Raynesm</name></author><author><name sortKey="Yuenm, Ct" uniqKey="Yuenm C">CT Yuenm</name></author><author><name sortKey="Feizi, T" uniqKey="Feizi T">T Feizi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schenkel, Ar" uniqKey="Schenkel A">AR Schenkel</name></author><author><name sortKey="Kingry, Lc" uniqKey="Kingry L">LC Kingry</name></author><author><name sortKey="Slayden, Ra" uniqKey="Slayden R">RA Slayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fodil Cornu, N" uniqKey="Fodil Cornu N">N Fodil-Cornu</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Abolins, Stephen" sort="Abolins, Stephen" uniqKey="Abolins S" first="Stephen" last="Abolins">Stephen Abolins</name><name sortKey="Drescher, Paul" sort="Drescher, Paul" uniqKey="Drescher P" first="Paul" last="Drescher">Paul Drescher</name><name sortKey="Hafalla, Julius C R" sort="Hafalla, Julius C R" uniqKey="Hafalla J" first="Julius C. R." last="Hafalla">Julius C. R. Hafalla</name><name sortKey="Hughes, Louise" sort="Hughes, Louise" uniqKey="Hughes L" first="Louise" last="Hughes">Louise Hughes</name><name sortKey="King, Elizabeth C" sort="King, Elizabeth C" uniqKey="King E" first="Elizabeth C." last="King">Elizabeth C. King</name><name sortKey="Lazarou, Luke" sort="Lazarou, Luke" uniqKey="Lazarou L" first="Luke" last="Lazarou">Luke Lazarou</name><name sortKey="Raynes, John G" sort="Raynes, John G" uniqKey="Raynes J" first="John G." last="Raynes">John G. Raynes</name><name sortKey="Riley, Eleanor M" sort="Riley, Eleanor M" uniqKey="Riley E" first="Eleanor M." last="Riley">Eleanor M. Riley</name><name sortKey="Viney, Mark E" sort="Viney, Mark E" uniqKey="Viney M" first="Mark E." last="Viney">Mark E. Viney</name><name sortKey="Weldon, Laura" sort="Weldon, Laura" uniqKey="Weldon L" first="Laura" last="Weldon">Laura Weldon</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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